A Study on Correlation of Multislice CT Angiography Grade with Microvessel Density of Pancreatic Cancer<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

陈克敏　陆勇　林晓珠　凌华威

上海交通大学附属瑞金医院放射科

Abstract

Objective：To investigate the correlation of multislice CT angiography grade with microvessel density of pancreatic cancer.

Methods：36 patients with pancreatic cancer were graded the vascular involvement with multislice CT angiography by Loyer classification. The microvessel density value of the surgical resections were measured with CD34 IHC staining.

Results：36 patients with pancreatic cancer were classified by Loyer classification，11 cases belonged to Grade A～B, 18 cases brlonged to Grade C～D, 7 cases belonged to Grade E～F. The microvessel density of them were 31.35±9.36，45.05±8.33 and 59.35±3.47, respectively.

Conclusion：The microvessel density of pancreatic cancer correlated with multislice CT angiography grade(r_s=0.920).

Key words：Pancreatic Cancer; Microvessel Density; Multislice CT Angiography

多层螺旋CT血管造影（MSCTA）技术的出现和发展提高了胰腺癌的诊断水平，尤其对肿瘤侵犯血管程度的分级评估，为判断手术可切除性提供了较可靠的依据^[1,2]。目前有研究表明微血管密度可直接反映肿瘤微血管生长状况，胰腺癌的微血管密度（MVD）显著高于正常组织^[3]。本文研究胰腺癌微血管密度水平与多层螺旋CT血管造影分级之间的关系，探讨CTA在反应胰腺癌微循环方面的可能性以及胰腺癌血管侵犯与微循环状态的关系。