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Experimental Study on the Feasibility and Safety of Microwave Ablation for Secondary Splenomagely and Hypersplenism in a Canine Model<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />
王旸 梁萍 盛林 王月香 肖秋金
解放军总医院超声科，北京 100853
Yang Wang , Ping Liang , lin Sheng , Yue-xiang Wang et al
Department of Ultrasound, PLA General Hospital, Beijing, 100853, China
Abstract
Objective：To evaluate the feasibility and safety of microwave ablation in the treatment of secondary splenomagely and hypersplenism in a canine model.
Methods： Congestive splenomegaly was induced by ligation of splenic vein and its collateral branches in fourteen healthy adult mongrel dogs. Microwave ablation of spleen was performed via laparotomy at different combinations of energy output and radiation time (40W450s, 50W360s, 60W300s, 70W257s) with an exposed antenna length of 27mm. Ultrasound and contrast-enhanced MRI were used to observe the therapeutic response. Volume of the ablation zone was calculated by MRI volumetry. Histopathologic examination of the ablation zone was performed under light miscroscope.
Results：Microwave application led to complete coagulative necrosis in all ablation zones. The contour of the ablation zone could be nicely depicted on ultrasound and MRI which correlated well with that of gross specimen. An output of 70W showed the highest efficacy in creating large ablation zones. No severe complication occurred except two abscesses in two dogs.
Conclusion：Microwave ablation of the spleen is a safe and feasible therapy in the treatment of secondary splenomagely and hypersplenism. The ablation volume could be effectively controlled and the therapeutic result could be reliably assessed by imaging methods This technique may become a promising spleen-sparing treatment to relieve the symptoms of hypersplenism.
Keywords：Microwave ablation; Interventional therapy; Splenomagely; Hypersplenism. | 
