<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

Application of Ultrasonic and Biomechanical methods on the Pulmonary Artery：A Methodological study on Arterial Wall Mechanics

陈明¹ 刘怡¹ 刘盛林¹ 余源² 戴峥² 汪毅² 丁云川² 张曙翔³

¹ 同济大学附属东方医院功能检查中心，上海，200120

² 昆明市延安医院，650051

³ 云南师范大学数学学院，650091

Abstract

　　Objective：New method for measuring arterial wall mechanics on the pulmonary artery（PA） was investigated by combination of ultrasound with biomechanical method.

　　Methods：Traditional biomechanical measurement in rat with pulmonary hypertension（PH） and method combined with ultrasound and biomechanical detection in patients with PH were completed. All cases were underwent right heart catheterization. PA pressure and dimensions of two－dimensional images were recorded measured at 10 points within systole. The data of mechanical parameters of stress－strain relation of PA were obtained from constitutive equations for biomechanical measurement.

　　Results：Material constants a and b were decreased significantly in groups of PH compared with control in both rat experiment and human study.

　　Conclusion：Ultrasonic and biomechanical method of PA would be useful in predicting  property and pathological process of PH，which would provide a new way for detection of arterial wall mechanics.

　　Key words：Echocardiography，Biomechanics，Pulmonary Artery

　　力在肺动脉高压（PH）的肺动脉（PA）血管的细胞和分子水平发病机制上有着重要的作用^[1]，但是传统的力学研究采用离体血管测量，尚不能用于临床实际。本研究探索将超声成像技术引入到力学研究中，试用超声与生物力学相结合的方法，在人体分析PA超声生物力学常数变化的可行性。

材料与方法

　　一、动物实验

　　1.慢性PH动物模型及生物力学测量^[2]

　　取Whister 大鼠24只（平均体重202.35g）在低氧下饲养45天－60天，正常对照大鼠24只。在PA测压后分离PA干及分支^[3]，将受检的离体PA血管置于供氧的Krebs溶液中，对PA从0－30mmHg进行载荷试验，按每一步加5mmHg的固定递增量，在低倍显微镜下测量PA血管径进行测量，然后输入到自制生物力学显微图像处理系统。