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CT Diagnosis of Diffuse Brochioloalveolar Carcinoma
李惠民 肖湘生 于 红 刘士远 李成洲 杨春山
200003 第二军医大学附属长征医院影像科
Li Huimin,Xiao Xiangsheng,Yu Hong,et al.
Department of Radiology,Changzheng Hospital,The Second Military Medical University,Shanghai 200003
Purpose:To study the CT diagnostic characteristics of diffuse bronchioloalveolar carcinoma (DBAC).
Materials and Methods:The CT features of pathologically verified DBAC in 23 patients were retrospectively analyzed. Thirteen of them were misdiagnosed pneumonitis, tuberulosis and metastasis when first-time examined.
Results:The manifestation of DBAC were classified into three types:multi-nodular(5),massive(2) and pneumonia-like(16). Two cases with typical lobar distribution,3 with lobar consolidation and 4 with honeycombing suggested DBAC. Diffuse nodule,mass and patchy opacity did not suggest DBAC.
Conclusion:The DBAC had kinds of manifestation. Multinodule with typical lobar distribution,lobar consolidation with angiogram and bronchiologram, and honeycombing opacity were characteristic to suggest DBAC.
Keywords:Bronchioloalveolar carcinoma,diffused CT
细支气管肺泡癌(bronchioloalveolar carcinoma,BAC)是一类特殊的腺癌,有学者甚至提出将其作为一种肺癌独立类型来看待[1],因为它有着不同于其它腺癌的组织发生及形态学特点:多数以肺结构为间质支架,沿局部周围气腔扩散即伏壁式生长,肺结构无破坏,肿瘤分泌的粘液充满肺泡,常可见支气管充气征和空泡征,按其表现类型可分为二型或三型:①孤立病灶型,结节或片状,规则或不规则,大多在肺的外周部或胸膜下,由于具有较强的促结缔组织增生的作用,故多呈分叶状,伴有胸膜凹陷征,密度不均匀;②弥漫型(diffuse BAC,DBAC),包括多发结节型和肺炎样型,癌组织常累及数叶或双肺,呈多发结节或肺炎样,常误诊。国内外关于细支气管肺泡癌的影像诊断文献已有不少,但各文献中关于DBAC的误诊率仍然较高,实有再提醒、再探讨的必要。
材料和方法
收集经肺活检、痰检或经纤维支气管镜细胞学、手术等证实的弥漫型细支气管肺泡癌共23例,其中男性15例,女性8例,年龄51~80岁,平均66.5岁。临床一般性咳嗽14例,发热9例,大量白色泡沫痰4例,痰中带血5例,胸痛3例。首次CT误诊13例,分别误为肺部炎症7例,肺结核3例,肺转移瘤3例;其余10例诊断为肺癌2例,直接诊断为肺泡癌8例。 |