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Department of Radiology，Seoul National University Hospital. Korea HRCT of diffuse panbronchiolitis

陈起航 JM Goo JG Im

¹Chen Qihang，²JM Goo，²JG Im.

ABSTRACT

　　PURPOSE：we prospectively studied high－resolution CT manifestations of 22 diffuse panbronchiolitis （DPB）.

　　MATERIAL AND METHODS：All cases were diagnosed histologically.HRCT findings were analyzed.

　　RESULTS：The CT findings of DPB included subpleural diffuse small rounded opacities （100％），bronchial wall thickening （100％），dilation of small bronchi or bronchioles （100％），tree－in－bud pattern（95.5％），thickening of interlobular septa （68.2％），focal hyperinflation （63.6％）.Those findings were distributed on bilateral lower lobe on all patients，right middle lobe （95.5％），right upper lobe（86.4％），left lingular lobe （59.1％），left upper lobe （50％）.

　　CONCLUSION：The typical findings of DPB were diffuse subpleural small rounded opacities，tree－in－bud pattern，dilation of small bronchi and bronchioles，with bilateral lower lobe distributed predominantly. HRCT has an important value in diagnosis and differential diagnosis of DPB.

　　Key words：diffuse panbrochiolitis HRCT

　　弥漫性泛细支气管炎是一种呼吸性细支气管的慢性炎症，且其原因及发病机制不明。这种疾病几乎仅发生于亚洲，尤其是日本、韩国和中国。在美国和欧州国家极为罕见。临床上泛细支气管炎主要呈慢性阻塞性肺病及缺氧症状，早期症状主要是慢性咳嗽，活动性呼吸困难，进一步发展可表现为发热、黄痰、晚期为咳脓痰、最后出现呼吸衰竭。其组织学特征是呼吸性支气管壁增厚并有淋巴细胞、浆细胞和组织细胞浸润、呼吸性细支气管狭窄、晚期可见近端终末细支气管的扩张。