|
<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />
Study on the Correlation between Spiral CT Features and Expression of PTEN，bFGF in Gastric Carcinoma
高剑波 李辉 陈学军 杨学华 郭华 周志刚 岳松伟
GAO Jian－bo*，LI Hui，CHEN Xue－jun，YANG Xue－hua，GUO Hua，ZHOU Zhi－gang，YUE Song－wei.
*Department of Radiology，<?xml:namespace prefix = st1 ns = "urn:schemas-microsoft-com:office:smarttags" />First Hospital，Zhengzhou University，Zhengzhou 450052，China
Abstrast
Objective：To investigate the spiral CT features of gastric carcinoma in the invasion and metastasis and its correlation with the expression of PTEN and bFGF.
Methods：Eighty－three patients were performed spiral CT plain scan and triphasic enhanced scans. The postoperative specimens were embedded with paraffin to obtain 5µm thickness tissues and stained with HE and immunohistochemistry. Spiral CT findings were comparated with the expression of PTEN and bFGF.
Results：1. The accuracy of spiral CT in T and N staging of gastric carcinoma was 94.0％ and 89.2％，respectively. 2. The expression of PTEN was 47.0％ in gastric carcinoma. The expression of PTEN in T3－4 and N1+2 gastric carcinoma was significantly lower than that of T2 and N0 gastric carcinoma，respectively（x2＝7.439，P＝0.006；x2＝6.511，P＝0.011）. 3. The expression of bFGF was 63.9％ in gastric carcinoma. The expression of bFGF in in T3－4 and N1+2 gastric carcinoma was significantly higher than that of T2 and N0 gastric carcinoma，respectively（x2＝7.314，P＝0.007；x2＝5.724，P＝0.017）. 4. The expression of PTEN was negatively corrrelated with that of bFGF （r＝－0.447，P＝0.000）.
Conclusion：The depth of invasion and lymph node metastasis detected by spiral CT were positively correlated with the expression of bFGF and negatively correlated with the expression of PTEN in gastric carcinoma. Spiral CT triphasic enhanced scans combined with biologic characteristics can improve diagnostic accuracy of gastric carcinoma in the invasion，metastasis and prognosis.
Key words：Stomach neoplasms；Tomography，X－ray computed；Neoplasm staging；Immunohistochemistry | 
