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Spiral CT features and expression of MMP－7 in esophageal carcinoma
高剑波 陈永强 周志刚 杨学华 陈学军 郭 华 岳松伟
GAO Jian－bo，CHEN Yong－qiang，ZHOU Zhi－gang，YANG Xue－hua，
CHEN Xue－jun，GUO Hua，YUE Song－wei
Abstract
Objective：To investigate the correlation between spiral CT features and expression of MMP－7 in esophageal carcinoma.
Methods：Spiral CT contrast－enhanced scans were performed in 46 patients with esophageal carcinoma before op eration. The specimens were stained with immunohistochemistry. Statistical analysis was performed with SPSS10.0 soft－ware.
Results：The accuracy of spiral CT contrast－enhanced scan in judging adjacent－infiltration and lymph node metastasis Was 89.13％（41 of 46）and 86.96％（40 of 46），respectively （P<0.001）. The MMP－7 positive rate was 60.87％.The positive rates of MMP－7 protein were 91.67％ and 50.00％ respectively in the adjacent－infiltration group and the non－adjacent－infiltration group （P<0.05），while being 87.50％ and 46.67％ respectively in the lymph node metastasis group and the non－lymphnode metastasis group （P<0.05）.
Conclusion：SCT contrast－enhanced scan is a valuable diagnostic technique for the patients of esophageal carcinoma before therapy. The adjacent－infiltration and the lymph node metastasis in SCT features are closely associated with the high expression of MMP－7，indicating that SCT features of esophageal carcinoma can reflect the expression of MMP－7 and the biological characteristic of tumor.
Keywords：Esophageal carcinoma； Tomography， X－ray computed； Matrix metalloproteinase－7 | 
